Montreal Neurological Institute Biobank: Clinical Biological Imaging and Genetic (C-BIG) Repository, Canada

Certification Status: Approved

Registration Status: Completed

Objective: Accelerating translational research in neurological disease The Neuroâ€™s CBIG-Repository is an Open-Science collection of biological samples, clinical information, imaging, and genetic data from patientâ€™s with neurological disease and healthy control subjects. This platform was created to allow patients to actively participate in advancing our understanding of the diseases affecting them. This unique collection of samples will empower researchers to develop insights into the biology underlying neurological disease, and facilitate the development of new treatments for patientâ€™s with neurological diseases. Data and samples collected in the CBIG-Repository will be made available to research teams with scientifically and ethically valid proposals around the world, congruent with Open Science principles.

Registered Biobank Name	Montreal Neurological Institute Biobank: Clinical Biological Imaging and Genetic (C-BIG) Repository
Biobank Leader	Sonia Lai
Country	Canada
Email for biobank inquiries	cbig.mni@mcgill.ca
Principal Investigator	Dr. Jason Karamchandani
Website	http://www.mcgill.ca/c-bigneuro/
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper	Poly - Collection aimed at supporting undetermined, multiple users with ethics approved research projects, through a defined access/application mechanism.

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).