National Healthcare Group Tissue Bank, Singapore

Certification Status: Approved

Registration Status: Completed

Objective: The National Healthcare Group (NHG) Tissue Bank is a composition of several satellite tissue banking sites across NHG institutions. As of May 2023, there are 15 satellite tissue bank sites. These sites perform tissue banking activities for future research; activities include harvesting tissues from consented donors, retaining and storing leftover tissue and samples and releasing tissue for research. Donors are recruited across various clinical disciplines, such as General Surgery, Dermatology, Haematology, Geriatric Medicine, Endocrinology and Renal Medicine. The NHG satellite tissue banks also support project-based tissue activities for Institutional Review Board (IRB)-approved Human Biomedical Research (HBR) and Clinical Trial (CT). This includes harvesting of additional tissue according to the research protocol, retaining leftover tissue and storing them for the duration of the project or beyond. The NHG Tissue Bank is overseen by the NHG Tissue Compliance Committee (TCC), which reviews and monitors the tissue banking activities to comply with the Singapore Human Biomedical Research Act (HBRA), NHG Tissue Bank Policy and institutional standards and procedures.

Registered Biobank Name	National Healthcare Group Tissue Bank
Biobank Leader	Suzanne Ho
Country	Singapore
Email for biobank inquiries	suzanne_hj_ho@nhg.com.sg
Principal Investigator	A/Prof Leong Khai Pang
Website	https://www.research.nhg.com.sg/wps/wcm/connect/romp/nhgromp/06+conducting+research/human+tissue+framework
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper	Poly - Collection aimed at supporting undetermined, multiple users with ethics approved research projects, through a defined access/application mechanism.

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).