cfDNA in Hereditary And High-Risk Malignancies (CHARM), Canada

Registration Status: Completed

Objective: cfDNA in Hereditary And High-Risk Malignancies (CHARM) is a research initiative that collects longitudinal plasma samples, tumour tissue, genomic/epigenomic data, and clinical data on individuals with a hereditary cancer syndrome, regardless of personal cancer history. Our goal is to improve early cancer detection by developing a blood test to predict cancer development in carriers using circulating DNA.

Registered Biobank Name	cfDNA in Hereditary And High-Risk Malignancies (CHARM)
Biobank Leader	Julia Sobotka - CHARM Program Manager
Country	Canada
Email for biobank inquiries	julia.sobotka@uhn.ca
Principal Investigator	Dr. Trevor Pugh
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).