Princess Margaret Living Biobank - PDX (sub core of University Health Network Oncology Biobank), Canada

Registration Status: Completed

Objective: The Princess Margaret Living Biobank (PMLB) offers Patient Derived tumor Xenograft (PDX) models, and associated turnkey services for research studies. All specimens (e.g. FFPE blocks, quick snap frozen and cryo-frozen tissues) are accessioned and stored at UHN Biobank. A PDX is created when tissue/cells from a patient’s tumor is implanted directly into an immunodeficient mouse host. Once established as a PDX model, the tumor specimen is extracted, divided and further expanded in multiple mice for cryo-banking and experimentation. Characterization of models adhere to minimal information standards associated with clinical information of their parent tumors, multi-omics data, and the generation and use of PDXs.

Registered Biobank Name Princess Margaret Living Biobank - PDX (sub core of University Health Network Oncology Biobank)
Biobank Leader Nhu-An Pham
Country Canada
Email for biobank inquiries npham@uhnresearch.ca
Principal Investigator Ming Sound Tsao
User Type
  • Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties
  • Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group
  • Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper
Biospecimen Collected: