cfDNA in Hereditary And High-Risk Malignancies (CHARM), Canada

Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties
Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group
Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Registration Status: Completed

Objective: cfDNA in Hereditary And High-Risk Malignancies (CHARM) is a research initiative that collects longitudinal plasma samples, tumour tissue, genomic/epigenomic data, and clinical data on individuals with a hereditary cancer syndrome, regardless of personal cancer history. Our goal is to improve early cancer detection by developing a blood test to predict cancer development in carriers using circulating DNA.

Registered Biobank Name	cfDNA in Hereditary And High-Risk Malignancies (CHARM)
Biobank Leader	Julia Sobotka - CHARM Program Manager
Country	Canada
Email for biobank inquiries	julia.sobotka@uhn.ca
Principal Investigator	Dr. Trevor Pugh
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Biospecimen Collected: