Biomarkers in CF, Canada

Registration Status: Completed

Objective: To identify promising novel candidate plasma and sputum biomarkers that indicate acute pulmonary exacerbations in CF. Using a non-targeted approach, we will interrogate the plasma and sputum proteome to discover novel candidate biomarkers that change in levels of expression from stable to exacerbation state. The central hypothesis of this study is that plasma and sputum biomarkers reflective of underlying disease activity can be monitored to diagnose exacerbations.

Registered Biobank Name	Biomarkers in CF
Biobank Leader	Alicia Murdoch
Country	Canada
Email for biobank inquiries	amurdoch@providencehealth.bc.ca
Principal Investigator	Dr. Bradley Quon
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).