HPV_DNA_Study, Canada

Certification Status: Approved

Registration Status: Completed

Objective: Primary Objectives: To evaluate the prognostic significance of detectable plasma HPV DNA following radical chemoradiation in patients with locally advanced cervical cancer. Secondary Objectives: To determine if plasma HPV DNA is more accurate than FDG-PET scan in identifying residual/recurrent disease at 3 months post chemoradiation in locally advanced cervical cancer.

Registered Biobank Name	HPV_DNA_Study
Biobank Leader	Zhen Zhao
Country	Canada
Email for biobank inquiries	zhen.zhao@uhnresearch.ca
Principal Investigator	Scott V Bratman
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper	Mono - Collection aimed at supporting a specific, single research project

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).