Princess Margaret Living Biobank - Organoid (sub core of UHN Biobank), Canada

Registration Status: Completed

Objective: The Princess Margaret Living Biobank (PMLB) offers Patient Derived tumor Organoid (PDO) models, and associated turnkey services for research studies. All specimens (e.g. FFPE blocks, quick snap frozen and cryo-frozen organoids) are accessioned and stored at UHN Biobank. A PDO is created when tissue/cells from a patient’s tumor are grown in 3D matrix with specific media. Once established as a PDO model, the organoid models is cryo-banked. Characterization of models include mycoplasma testing, histophathological evaluation, STR profiling and genomic profiling. Charaterization of models adhere to minimal information standards associated with clinical information of their parent tumors, multi-omics data, and the generation and use of PDOs.

Registered Biobank Name Princess Margaret Living Biobank - Organoid (sub core of UHN Biobank)
Biobank Leader Nikolina Radulovich
Country Canada
Email for biobank inquiries nikolina.radulovich@uhnresearch.ca
Principal Investigator Ming Sound Tsao
Website
User Type
  • Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties
  • Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group
  • Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper
Biospecimen Collected:
Cohort Highlights