The Living Tumor Lab, Canada

Registration Status: Completed

Objective: The LTL transplantable cancer tissue xenografts are based on grafting patients’ biopsy or excised tumor tissue into the subrenal capsule graft site (sub-renal capsule xenografting). The high vascularity of this site, compared to subcutaneous and orthotopic sites, allows more adequate supply of nutrients to the graft important for maintaining tumor heterogeneity. Thus, the cancer tissue xenografts established in the Living Tumor Laboratory have the following advantages: • High take rate. We have consistently achieved high tumor take rates (>95%) for a variety of low and higher grade malignancies. • Retention of major characteristics of the original tumors. The tumor tissue lines retain major genotypic and phenotypic characteristics (histopathology, heterogeneous cell population, target expression and target dependence) of the patient’s original tumor, including drug sensitivity/resistance. Early samples are stored frozen in liquid nitrogen. • Novel model of metastasis. Many of our transplantable living tumor tissue lines exhibit predictable macroscopic (high-volume) metastases. • High reproducibility. Large amounts of tumor tissue can be grown readily. The Living Tumor Laboratory has established more than 200 transplantable human cancer tissue lines in SCID mice directly derived from a wide range of primary tumors from patients.

Registered Biobank Name The Living Tumor Lab
Biobank Leader Yuzhuo Wang
Country Canada
Email for biobank inquiries nwong@bccrc.ca
Principal Investigator Yuzhuo Wang
User Type
  • Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties
  • Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group
  • Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper
Biospecimen Collected: