MIRAE, Canada

Registration Status: Completed

Objective: The purpose of the MIRAE Biobank is to facilitate future on cancer immunotherapies and traditional autoimmune and autoinflammatory diseases. Cancer immunotherapy refers to various treatments that enhance the power of human immune cells to seek out and destroy cancer cells. These treatments can lead to remarkable cancer remissions, but their use is sometimes limited by significant autoimmune toxicities. The goal of the study is to answer questions such as why some patients taking a cancer immunotherapy develop immune side effects while others do not, and what are the immune mechanisms responsible for these side effects during treatment. Answering these questions will lead to the development of more personalized treatment for patients with cancer requiring immunotherapy in the future. By comparing patients with immune side effects from immunotherapy with patients with traditional autoimmune and autoinflammatory diseases, we also seek to gain novel insights into naturally occurring autoimmune diseases.

Registered Biobank Name	MIRAE
Biobank Leader	Dr Marie Hudson
Country	Canada
Email for biobank inquiries	marie.hudson@mcgill.ca
Principal Investigator	Dr Marie Hudson
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).