Comprehensive Phenotyping of Exacerbation in CF (CPEX-CF), Canada

Registration Status: Completed

Objective: Cystic fibrosis (CF) patients develop flare-ups of lung infection, known as pulmonary exacerbations (PEx). PEx greatly reduce quality of life, can result in permanent loss of lung function, and are often treated with antibiotics. We will attempt to develop tools and mechanism to identify various CF patient populations and how they may respond during PEx using biomarkers (RNA and/or proteins). The aim is to diagnose and treat flare-ups earlier and more appropriately before permanent worsening of symptoms occur.

Registered Biobank Name	Comprehensive Phenotyping of Exacerbation in CF (CPEX-CF)
Biobank Leader	Dr. Bradley S. Quon
Country	Canada
Email for biobank inquiries	bradley.quon@hli.ubc.ca
Principal Investigator	Dr. Bradley S. Quon
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).