Mukherjee Lung Cancer Liquid Biopsy Project, Canada

Registration Status: Completed

Objective: Circulating tumor DNA (ctDNA) is mutated DNA that is released from cancer cells. In patients who are diagnosed with lung cancer, ctDNA is possibly found in airway secretions and blood to be used as a biomarker for the detection of lung cancer recurrence after lung resection surgery. Nucleic acids are extracted from the peripheral blood, bronchoalveolar lavage (BAL), and sputum and digital PCR is subsequently used to detect ctDNA. This project aims to test the viability and feasibility of using this new biomarker for early detection of the recurrence of non-small cell lung cancer (NSCLC).

Registered Biobank Name	Mukherjee Lung Cancer Liquid Biopsy Project
Biobank Leader	Manali Mukherjee
Country	Canada
Email for biobank inquiries	mukherj@mcmaster.ca
Principal Investigator	Manali Mukherjee
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).