School of Public Health Tissue Repository (SPHTR), Singapore

Certification Status: Approved

Registration Status: Completed

Objective: As the School is increasingly getting more research projects requiring the storage of the investigatorsâ€™ bio-samples, the School is establishing a centralized bio-sample storage system (CBSS) with database managed by an independent IT team to track specimens held at the School Tissues Repository (SPH-TR) to cater to such needs. The objective of implementing the CBSS is to make it easy for the investigators to focus on their research and avoid unnecessary and costly investment in equipment, staffing and storage facilities for their samples. All sample storage facilities will be purchased, owned and maintained by the School. Cost recovery from the investigators is essential for the School to maintain the TR facilities and the operational costs of providing such services. Operating procedures for the management of such CBSS can be effectively standardized and reviewed regularly by the Tissues Repository Advisory Committee (TRAC) to ensure our operations are in accordance with national guidelines and international best practices.

Registered Biobank Name	School of Public Health Tissue Repository (SPHTR)
Biobank Leader	Ezra Chiam (Senior Assistant Director)
Country	Singapore
Email for biobank inquiries	ephcsle@nus.edu.sg
Principal Investigator	Prof Teo Yik Ying (Dean)
Website	www.sph.nus.edu.sg
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper	Poly - Collection aimed at supporting undetermined, multiple users with ethics approved research projects, through a defined access/application mechanism.

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).