The John Walton Muscular Dystrophy Research Centre Biobank, United Kingdom

Registration Status: Completed

Objective: The John Walton Muscular Dystrophy Research Centre Biobank is a biorepository, containing well-characterised, high-quality specimens. Since 2008, over 18,000 anonymised specimens have been donated by patients attending JWMDRC clinics, participating in clinical trials or participating in disease natural history studies. Specimens from the biorepository have been distributed to researchers not only within Newcastle University but around the globe, with an aim of facilitating translational research of neuromuscular disease (research from the bench to the bedside).

Registered Biobank Name	The John Walton Muscular Dystrophy Research Centre Biobank
Biobank Leader	Daniel Cox
Country	United Kingdom
Email for biobank inquiries	jwmdrc.biobank@newcastle.ac.uk
Principal Investigator	Professor Volker Straub
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).