Vancouver Brain Tumor Biobank, Canada

Registration Status: Completed

Objective: The purpose of Vancouver Brain Tumor Biobank (VBTB) is to serve as a resource for facilitating future clinical, molecular and genetic research studies that will expand our understanding of the biology of brain tumors. Such insights will be crucial in the scientific development of relevant treatments for these pathologies. VBTB will store fresh frozen and formalin-fixed, paraffin-embedded brain tumor tissue samples, as well as blood and CSF specimens, from a wide spectrum of patients with intracranial neoplastic lesions, including primary tumors and metastatic lesions, with the intention of these samples being made available as a resource to researchers for REB-approved neuro-oncology projects in the future. In addition, live tissue will be used to derive patient-derived 2D and 3D cell models for performing functional assays.

Registered Biobank Name	Vancouver Brain Tumor Biobank
Biobank Leader	Dr. Serge Makarenko
Country	Canada
Email for biobank inquiries	Serge.Makarenko@vch.ca
Principal Investigator	Dr. Serge Makarenko
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).