CHAIN Biobank, Portugal

Registration Status: Completed

Objective: The Comprehensive Health Biobank (CHAIN) is located at Nova medical school and is powered by the Comprehensive Health Research Centre (CHRC) research Unit. Its main mission is to provide the most trusted biological samples available (serum, DNA, organoids, bone, cell lines) to support biomedical, clinical, epidemiological, and translational research activities, especially in the areas of health promotion and chronic and high-burden diseases, thus allowing to strengthen research quality and outcome as well as encouraging national and international research collaborations.

Registered Biobank Name	CHAIN Biobank
Biobank Leader	Maria Assuncao
Country	Portugal
Email for biobank inquiries	maria.assuncao@nms.unl.pt
Principal Investigator	Ana Rodrigues, Ana Oliveira, Maria Assuncao
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).