Princess Margaret Living Biobank - PDX (sub core of University Health Network Oncology Biobank), Canada

Registration Status: Completed

Objective: The Princess Margaret Living Biobank (PMLB) offers Patient Derived tumor Xenograft (PDX) models, and associated turnkey services for research studies. All specimens (e.g. FFPE blocks, quick snap frozen and cryo-frozen tissues) are accessioned and stored at UHN Biobank. A PDX is created when tissue/cells from a patientâ€™s tumor is implanted directly into an immunodeficient mouse host. Once established as a PDX model, the tumor specimen is extracted, divided and further expanded in multiple mice for cryo-banking and experimentation. Characterization of models adhere to minimal information standards associated with clinical information of their parent tumors, multi-omics data, and the generation and use of PDXs.

Registered Biobank Name	Princess Margaret Living Biobank - PDX (sub core of University Health Network Oncology Biobank)
Biobank Leader	Nhu-An Pham
Country	Canada
Email for biobank inquiries	npham@uhnresearch.ca
Principal Investigator	Ming Sound Tsao
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).