Biobanque des maladies digestives du CRCHUS, Canada

Certification Status: Approved

Registration Status: Completed

Objective: DESCRIPTION OF THE DISEASES UNDER STUDY The digestive diseases under study can involve the following organs: mouth, salivary glands, pharynx, esophagus, stomach, small intestine, large intestine (cecum, colon, rectum), liver, gallbladder, and pancreas. Among the digestive diseases mainly studied at the moment we find colorectal and pancreatic cancers. DESCRIPTION OF THE BANKâ€™S OBJECTIVES Research on digestive diseases has had a significant impact on our understanding of these diseases, leading to better treatment options, improved outcomes, and a better quality of life for patients. But further research is necessary to better understand how digestive diseases start and evolve though the body, what causes them, how to improve treatment, the mechanisms of resistance to treatments and their long-term effects. Such research requires researchers to study cells with the disease and healthy derived from patients affected by these diseases and from unaffected people. The objective of the bank is to provide research teams with biological material (blood, tissue, fluid, stool, etc.) as well as with clinical data to facilitate a better understanding of the diseases. The studies carried out on biological material and data may generate new biological derivatives (living or non-living) or data that can be included into the bank.

Registered Biobank Name	Biobanque des maladies digestives du CRCHUS
Biobank Leader	Karine Tremblay
Country	Canada
Email for biobank inquiries	karine.tremblay2@usherbrooke.ca
Principal Investigator	Julie Carrier
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper	Poly - Collection aimed at supporting undetermined, multiple users with ethics approved research projects, through a defined access/application mechanism.

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).