Alberta Diabetes Institute IsletCore, Canada

Certification Status: Approved

Registration Status: Completed

Objective: Isletcore is a human islet isolation, research, distribution, and biobanking facility located in a state-of-the art laboratory on the 5th floor of the Alberta Diabetes Institute. Our goal is to isolate, bank, and distribute human islets specifically for research purposes from donor pancreas that would not otherwise be used in clinical transplantation. Our research-specific focus allows the use of organs from donors with type 1 diabetes (T1D) and type 2 diabetes (T2D), as well as other non-standard donors so that researchers can better understand the processes contributing to islet health and dysfunction. We isolate and distribute human islets from a range of donor types to laboratories worldwide for the study of diabetes. We bank functional islets by cryopreservation, for future research and use with emerging technologies to facilitate diabetes research.

Registered Biobank Name	Alberta Diabetes Institute IsletCore
Biobank Leader	Dr Patrick MacDonald
Country	Canada
Email for biobank inquiries	pem@ualberta.ca
Principal Investigator	Dr Patrick MacDonald
Website	http://www.bcell.org/isletcore.html
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper	Poly - Collection aimed at supporting undetermined, multiple users with ethics approved research projects, through a defined access/application mechanism.

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).