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AgingResearchBiobank, United States

Objective: The National Institute on Aging (NIA) at the National Institutes of Health (NIH), U.S. Department of Health and Human Services (HHS), leads the federal government in conducting and supporting research on aging and the health and well-being of older people. Our research ranges from the study of basic cellular changes that accompany the aging process to the examination of the biomedical, social, and behavioral aspects of growing older. Our main goal is to understand the nature of aging and the aging process, and diseases and conditions associated with growing older, in order to extend the healthy, active years of life. NIA conducts and funds various longitudinal and clinical studies on aging that generate or have generated a collection of biospecimens and related phenotypic and clinical data. In 2018, the NIA's Division of Geriatrics and Clinical Gerontology established the AgingResearchBiobank to provide a state-of-the-art inventory system for the storage and distribution of these collections to the broader scientific community. Over the years, study collections have made significant contributions to public health and will continue to do so. Aging research will be expanded through the use of such collections to address new promising scientific questions targeting the development of prognostics, markers, and therapeutics for conditions related to aging and to provide a better understanding of the aging process. Collections included in the AgingResearchBiobank were built over many years from studies that carefully selected subjects and are available in a finite quantity. Each biospecimen is unique and cannot be replaced. Together with the opportunity to potentially pool data across study collections significantly increases the value and power of future research findings from the resources offered by the AgingResearchBiobank. The Biobank currently holds approximately 3 million samples from a variety of material types (……) and related phenotypic and clinical data from the following study collections: • The Study of Women Health Across the Nation (SWAN), funded since 1994, is the largest source of data across the menopause transition, with approximately 1.7 million samples. • The Lifestyle Interventions and Independence for Elders (LIFE) is a phase III trial in 1635 sedentary persons 70 to 89 years, at high risk for major mobility disability (inability to walk 400 meters). • The Osteoporotic Fractures in Men Study (MrOS) is a multi-center observational study of 5,994 men. • The Study of Osteoporotic Fractures (SOF), initially established to identify the risk factors associated with osteoporotic fractures in postmenopausal women aged 65 and older, expanded its scope over time to include assessment of sleep, cognitive function, osteoarthritis, breast cancer, cognitive function, and healthy aging. SOF concluded in 2017 after 31 years of research. • The Multicenter Osteoarthritis Study (MOST) is the first large-scale epidemiologic study to focus on symptomatic osteoarthritis of the knee in a community-based sample of adults with or at high risk for knee osteoarthritis (3026 participants). • The ENabling Reduction of Low-Grade Inflammation in SEniors) Pilot Study, with 289 participants, tested the use of anti-inflammatory interventions in preventing major mobility disability by improving or preserving walking ability. • The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE). In addition to its biospecimen repository (serum, plasma, urine, buffy coat, muscle (vastus lateralis), and fat (subcutaneous abdominal), its database contains information on physiological and immune functions, physical performance, psychological outcomes, dietary records, disease risk factors, blood chemistry, and hematology. • The Successful Aging after Elective Surgery Study (phase I) was performed to identify novel risk factors for delirium, including blood-based biomarkers and cognitive reserve markers, and to describe the long-term effects of delirium on cognitive and functional capacity in older adults following elective surgery. • The Testosterone Trials (TTrials), a collection of seven trials that investigated the efficacy of increasing the serum testosterone level of older men (w/ low serum testosterone) to that of young men. • The Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) was a falls prevention trial with > 5000 participants, testing an intervention utilizing a falls-care manager. This is a collection of data only.