Hospital for Endocrine Surgery Research Center Biobank, United States

Registration Status: Completed

Objective: The Hospital for Endocrine Surgery research Center (HESRC) Biobank is a prospective, hospital-based biorepository established at the Hospital for Endocrine Surgery (Tampa, Florida, USA) to support genetic, molecular, and translational research on endocrine tumors and related conditions. It systematically collects and stores high-quality biological specimens — including tumor tissue, adjacent normal tissue, serum, plasma, urine, lymph, and germline DNA (from blood and/or saliva) — together with richly annotated longitudinal clinical data from patients undergoing surgery for thyroid, parathyroid, and adrenal tumors or associated endocrine disorders. Samples are obtained during clinically indicated procedures (with excess tissue used post-diagnosis) or via minimally invasive research collections coordinated with routine care. All materials are de-identified, assigned unique codes, and stored indefinitely in a secure, encrypted system (eLabNext) under strict confidentiality and HIPAA-compliant protocols. Primary aims include enabling next-generation sequencing (NGS), whole-exome sequencing, transcriptomics, epigenomics, proteomics, and functional studies to identify somatic/germline mutations, molecular pathways, biomarkers for early detection/prognosis/therapy, gene-environment interactions, and pharmacogenomic predictors of treatment response and recurrence. The repository supports future hypothesis-driven projects, with annual accrual targets of up to 3,000 participants and collection from ≥80% of eligible surgical cases. The biobank operates under WCG IRB approval, follows Common Rule and Belmont Report principles, obtaining explicit informed consent from adult participants only.

Registered Biobank Name	Hospital for Endocrine Surgery Research Center Biobank
Biobank Leader	Fabio Faucz
Country	United States
Email for biobank inquiries	fabio.faucz@hcahelthcare.com
Principal Investigator	Fabio Faucz
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).