St. Jude Biorepository, United States

Registration Status: Completed

Objective: OVERVIEW The mission of the St. Jude Biorepository is to provide biobanking and specimen processing services to investigators across the institution. It is the central, institutional repository of biological specimens at St. Jude Children's Research Hospital embedded in the Department of Pathology. As one of the first College of American Pathology-accredited biorepositories, St. Jude’s center processes, stores, and distributes specimens for numerous clinical trials. Additionally, the Biorepository banks left-over diagnostic specimens for future research, under the TBANK protocol. IMPACT The St. Jude Biorepository was launched in the mid 1970s with blood and bone marrow samples from childhood leukemia patients. Now, the library contains more than 500,000 specimens donated by current patients, long-term survivors, participants in St. Jude clinical trials worldwide, and children with non-malignant blood disorders such as sickle cell disease and bone marrow failure syndromes. Tissue archives The Archives contain samples of human solid and brain tumors, uninvolved tissues and cell suspensions of tumor and normal hematopoietic cells collected at diagnosis, and at various subsequent time points within the course of therapy. DNA from diseased and uninvolved specimens is extracted upon request. Serum and plasma collected at diagnosis and at intermittent periods are also banked. Tumor tissues are stored in aliquots of snap-frozen tissue blocks and as extracted DNA. In addition, the Biorepository also banks urine, cerebrospinal fluid, ascites, pleural fluid, FFPE unstained slides, and FFPE scrolls.

Registered Biobank Name St. Jude Biorepository
Biobank Leader Jason Chiang
Country United States
Email for biobank inquiries jason.chiang@stjude.org
Principal Investigator Jason Chiang
Website
User Type
  • Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties
  • Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group
  • Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper
Biospecimen Collected:
Cohort Highlights